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Additional evidence in support of the metabolic dysregulation in PKD came from the interesting observation that PKD animal models displayed an upregulation of the miR-17∼92 cluster and that, in line with this, genetic deletion of the cluster in mice, or treatment with anti- miR-17∼92 anti-sense oligonucleotides resulted in a drastic improvement of polycystic kidney disease (377)
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None the less, the observation was correct and was published in the Journal of Clinical Oncology in 2007 [4]
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