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1189,1190 Inhibitors of the JAK-STAT pathway, such as tofacitinib, possess strong anti-inflammatory properties, significantly decreasing the mitochondrial membrane potential, mass, and ROS generation in RA synovial fibroblasts
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and (ii) the evolution of the heme oxygenase system, which not only degrades excess heme, but also is up-regulated when heme levels exceed beyond its normal requirement
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