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Structural and functional abnormalities of the renal microcirculation, including endothelial dysfunction, impaired nitric oxide bioavailability and enhanced vasoconstrictor tone, reduce cortical and medullary perfusion and create a hypoxic microenvironment (Table 1, early-stage CKD can therefore be conceptualised as a set of overlapping injury axes—glomerular haemodynamic stress, tubular protein and nutrient overload, inflammatory and fibrotic remodelling, and microvascular dysfunction—that together shape the spatial pattern of kidney damage and its systemic consequences

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Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysis