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The main brain regions affected could be the prefrontal cortex (PFC) or the temporal lobe

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In terms of substrate profile, the m6A modification catalyzed by METTL3 has a broad RNA-type specificity, covering classical RNA molecules such as mRNAs, tRNAs and ribosomal RNA (rRNA)s, as well as regulatory RNAs, such as miRNA precursors and long-stranded non-coding RNAs (lncRNAs) (30)

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