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26,29,30,31 Acute precipitated withdrawal In Experiment 1, to establish the model and validate the behavioral scoring, pups were randomized within litter to receive either naloxone hydrochloride (1 mg/kg, intraperitoneal (i.p.)), a dose that has been shown to precipitate acute withdrawal in rats, 26,29,30,31 or an equal volume of saline

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doi: 10.1016/j.clnesp.2019.02.003