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Based on these caveats, any testing of new therapeutic interventions should be performed in human pathophysiologically relevant models including primary mouse or human hepatocytes, HepaRG cells, or the in vivo mouse model
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This work reveals a novel mechanism regulating lipoic arm-dependent enzymes and provides a new mechanistic link between RNS and cellular metabolism that has broad implications for physiological and pathological conditions involving RNS accumulation
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