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Thus, to gather additional evidence about the identity of the LDOX oxidation product, we performed enzymatic reactions in buffer containing H 2 18 O, exploiting the expected equilibrium between the gem-diol flavan-3,3,4-triol ( 4 ) and the corresponding ketone flavan-3-on-4-ol ( 7 ) (Fig

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9 , e1003225 (2013)