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Foresta et al suggested that hypotestosteronemia was related to the reduction of circulating EPCs in young hypogonadotropic hypogonadal men 52 , whereas the reduction of EPCs could be reversed by the testosterone replacement through a direct stimulatory effect on the bone marrow 53 , and the androgen receptor/VEGF/cyclin A-mediated mechanism may be involved in this process 54

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Interestingly, there is a positive correlation between depth and longevity (Cailliet et al., 2001) and the longest-living species do not appear to undergo reproductive senescence, with fecundity increasing monotonically with age, that would qualify this clade as a model of negligible senescence