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Pathophysiology of the intervertebral disc degeneration Intervertebral disc (IVD) degeneration is a progressive and multifactorial process that contributes to lumbar spine dysfunction and instability

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SIRT3 axis of mtUPR has indeed been shown to limit oxidative damages in stressed mitochondria by inducing the expression of the antioxidant enzyme superoxide dismutase (SOD) 2, through the activation of the nuclear transcription factor FOXO3, and potentiates the elimination of irreparable mitochondria by activating mitophagy targets [35]