padmini erythrocyte glutathione depletion Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis Size:#10(0.30mm)17M1 Nitric Oxide Accelerator by best deals

padmini erythrocyte glutathione depletion Glutathione-depleting mitochondria-targeting nanodrugs for stress amplification and immune activation via synergistic photodynamic therapy and cuproptosis Size:#10(0.30mm)17M1 Nitric Oxide Accelerator by best deals

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doi: 10.3389/fonc.2022.873293 174 KimKDBaeSCapeceTNedelkovskaHde RubioRGSmrckaAVet al

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Size:#10(0.30mm)17M1

To solve the paradox that pre-existing high concentrations of ROS in the TME can conversely inhibit immunity, the most advanced strategy is to develop multifunctional nanovaccines that “first clear, then activate.” Such vaccines can first use their material properties to scavenge the inhibitory ROS in the TME, creating a favorable environment for immune cells, and then strongly activate DCs by releasing immune agonists, ultimately triggering a systemic anti-tumor immunity [265]