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Using a total of 558 restraints that include 40 dihedral angles and 24 hydrogen bonds (Table 1) and 494 NOE restraints (intra—205, short—220 and medium—69), we calculated an ensemble of structures for SERF2 (Fig

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For most ALDH1 and ALDH2 isozymes, addition of cofactor initiates the esterase reaction, an effect thought to occur through increased nucleophilicity of the active site Cys302 (Takahashi et al., 1981)