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So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest
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On top of their action at a transcriptional level, literature recently highlighted the potential of (poly)phenols to exert some post-transcriptional regulation of genes through the modulation of non-coding RNA’s expression, called microRNAs (miRNAs), which can behave as gene regulators (Reference Milenkovic, Deval and Gouranton88,Reference Milenkovic, Jude and Morand89)
